Residue-Specialized Membrane Poration Kinetics of Melittin and Its Variants: Insight from Mechanistic Landscapes *

Zhi-Xiong Deng,Jing-Liang Li,Bing Yuan,Kai Yang

Fig. S4 (Color online) Formation process of an unstable U-pore under the action of melittin at $P/L$=1/43. (a) Snapshots showing different interaction states between melittin and membrane ("S" and "U"). One U-shaped peptide is tracked and colored green (with residue K7 in red), while the others are grey. (b), (c) Time-dependent evolution of the z-position (b) and tilt angle (c) of key residues during the interaction process, including G1, Q26, T11, and K7.