Residue-Specialized Membrane Poration Kinetics of Melittin and Its Variants: Insight from Mechanistic Landscapes *

Zhi-Xiong Deng,Jing-Liang Li,Bing Yuan,Kai Yang

Fig. S9 (Color online) (a) Amino acid sequences of a variant of MelP5, named MelP5'(A10T).Color codes are same as those in Fig. 1 in the main text. (b) Peptide aggregation on the membrane surface indicated by cluster number (top) and the peptide number in the largest cluster (bottom).$P/L=43$. The results shown here show the aggregation situation of MelP5'(A10T). It is found that,although the 10th residue is changed back from A to T in MelP5'(A10T) (Fig. S9(a)),its aggregation situation is almost the same as that of MelP5 (Fig. S9(b)).