Residue-Specialized Membrane Poration Kinetics of Melittin and Its Variants: Insight from Mechanistic Landscapes *
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Residue-Specialized Membrane Poration Kinetics of Melittin and Its Variants: Insight from Mechanistic Landscapes * |
| Zhi-Xiong Deng,Jing-Liang Li,Bing Yuan,Kai Yang |
| Fig. 5 (Color online) Different ability of different peptides, including melittin and its variants, to form "U" conformation during the membrane interactions. (a) Percentage of the peptides with U-shaped conformation during the membrane interaction process. Here, $P/L$=1/43. (b) Free energy profiles indicating the possibility to realize "U" conformation of each type of peptides. Inset shows definition of the CVs of $Z_N$ and $Z_{\rm kink}$. |
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