Residue-Specialized Membrane Poration Kinetics of Melittin and Its Variants: Insight from Mechanistic Landscapes *
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Residue-Specialized Membrane Poration Kinetics of Melittin and Its Variants: Insight from Mechanistic Landscapes * |
| Zhi-Xiong Deng,Jing-Liang Li,Bing Yuan,Kai Yang |
| Fig. 6 (Color online) Free energy landscape of the transmembrane insertion of a single melittin or MelP5. (a) Landscape with the CVs of $Z_N$ and $Z_{\rm kink}$. (b) Corresponding minimum free energy pathways obtained from (a). Red lines demonstrate two leaflets of the membrane. $N$ terminus and residue 11 (at the kink region) are colored in red and green, respectively. |
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