vatm | ATM activation rate | 1.2 (C min−1) |
datm | ATM maximum inactivation rate | 0.53 ($/\min $) |
vp53 | P53 maximum production rate | 0.95 (C min−1) |
dp53 | P53 maximum degradation rate | 1.2 ($/\min $) |
vmdm2 | Mdm2 maximum production rate | 0.153 (C min−1) |
kp | Mdm2 maximum phosphorylation rate | 0.65 ($/\min $) |
kq | Mdm2 dephosphorylation rate | 0.24 ($/\min $) |
kin | The rate of Mdm2 transfer from the cytoplasm to the nucleus | 0.14 ($/\min $) |
kout | The rate of Mdm2 transfer from the nucleus to the cytoplasm | 0.01 ($/\min $) |
dmdm2 | Mdm2c degradation rate | 0.034 ($/\min $) |
vmir | miR-34 maximum production rate | 0.035 (C min−1) |
dmir | miR-34 degradation rate | 0.05 ($/\min $) |
ρ0 | P53-dependent ATM inactivation proportional constant | 0.9 (\) |
ρ1 | ATM-dependent p53 activation proportional constant | 0.9 (\) |
ρ2 | Mdm2p-dependent p53 production proportional constant | 0.98 (\) |
ρ3 | Mdm2n-dependent p53 degradation proportional constant | 0.97 (\) |
ρ4 | P53-dependent Mdm2 production proportional constant | 0.98 (\) |
ρ5 | ATM-dependent Mdm2 phosphorylation proportional constant | 0.9 (\) |
ρ6 | P53-dependent miR-34 production proportional constant | 0.99 (\) |
k0 | Half-saturated concentration of p53-dependent ATM inactivation | 1 (C) |
k1 | Half-saturated concentration of ATM-dependent p53 activation | 0.3 (C) |
k2 | Half-saturated concentration of Mdm2p-dependent p53 production | 0.057 (C) |
k3 | The maximum half-saturated concentration of Mdm2n-dependent p53 degradation | 0.5 (C) |
k4 | Half-saturated concentration of p53-dependent Mdm2 production | 4.43 (C) |
k5 | Half-saturated concentration of ATM-dependent Mdm2 phosphorylation | 1 (C) |
k6 | Half-saturated concentration of p53-dependent miR-34 production | 0.8 (C) |
α | Proportional constant of miR-34-regulated half-saturated | |
| concentration of Mdm2n for p53 degradation | 0.9 (\) |
κ | Half-saturated concentration of miR-34-regulated half-saturated | |
| concentration of Mdm2n for p53 degradation | 1 (C) |
r0 | Mdm2n and Mdm2c degradation rate ratio | 1.7 (\) |
g0 | Mdm2p and Mdm2c degradation rate ratio | 3.58 (\) |