Exploring the influence of microRNA miR-34 on p53 dynamics: a numerical study*
Nan Liu(刘楠),Hongli Yang(杨红丽),Liangui Yang(杨联贵)
Table 1. Simulation parameters.
ParameterDescriptionValues (units)
vatmATM activation rate1.2 (C min−1)
datmATM maximum inactivation rate0.53 ($/\min $)
vp53P53 maximum production rate0.95 (C min−1)
dp53P53 maximum degradation rate1.2 ($/\min $)
vmdm2Mdm2 maximum production rate0.153 (C min−1)
kpMdm2 maximum phosphorylation rate0.65 ($/\min $)
kqMdm2 dephosphorylation rate0.24 ($/\min $)
kinThe rate of Mdm2 transfer from the cytoplasm to the nucleus0.14 ($/\min $)
koutThe rate of Mdm2 transfer from the nucleus to the cytoplasm0.01 ($/\min $)
dmdm2Mdm2c degradation rate0.034 ($/\min $)
vmirmiR-34 maximum production rate0.035 (C min−1)
dmirmiR-34 degradation rate0.05 ($/\min $)
ρ0P53-dependent ATM inactivation proportional constant0.9 (\)
ρ1ATM-dependent p53 activation proportional constant0.9 (\)
ρ2Mdm2p-dependent p53 production proportional constant0.98 (\)
ρ3Mdm2n-dependent p53 degradation proportional constant0.97 (\)
ρ4P53-dependent Mdm2 production proportional constant0.98 (\)
ρ5ATM-dependent Mdm2 phosphorylation proportional constant0.9 (\)
ρ6P53-dependent miR-34 production proportional constant0.99 (\)
k0Half-saturated concentration of p53-dependent ATM inactivation1 (C)
k1Half-saturated concentration of ATM-dependent p53 activation0.3 (C)
k2Half-saturated concentration of Mdm2p-dependent p53 production0.057 (C)
k3The maximum half-saturated concentration of Mdm2n-dependent p53 degradation0.5 (C)
k4Half-saturated concentration of p53-dependent Mdm2 production4.43 (C)
k5Half-saturated concentration of ATM-dependent Mdm2 phosphorylation1 (C)
k6Half-saturated concentration of p53-dependent miR-34 production0.8 (C)
αProportional constant of miR-34-regulated half-saturated
concentration of Mdm2n for p53 degradation0.9 (\)
κHalf-saturated concentration of miR-34-regulated half-saturated
concentration of Mdm2n for p53 degradation1 (C)
r0Mdm2n and Mdm2c degradation rate ratio1.7 (\)
g0Mdm2p and Mdm2c degradation rate ratio3.58 (\)