Balanced biosynthesis and trigger threshold resulting in a double adder mechanism of cell size control

Leilei Li

Table 1. The dynamics parameters and biological constants in the ATRQID system.

Constants/Parameters Symbol Value Reference Protein density g 0.25 g cm−3 [76] Molecular weight per ribosome R nR 7336aa [75] Molecular weight per metabolic protein T on average nT 325aa [70] Molecular weight per housekeeping protein P on average nQ 325aa [70] Protein degradation rate respectively dR, dT, dQ Given [71, 72] The efficiency of metabolic enzymes T k Given Ribosomal catalytic efficiency Σ Given The fractions of ribosomes engaged in making ribosomes R fR Optimized by growth rate Equation (A.23) The fractions of ribosomes engaged in making metabolic protein T fT Optimized by growth rate Equation (A.24) The fractions of ribosomes engaged in making housekeeping protein T fQ 0.45 [73] DNA replication initiation protein per origin threshold Ic Given Cell division initiation protein threshold Dc Given The average mass of amino acids mA 3000Da [74] DNA replication initiation protein synthesis rate constant KI Given Cell division initiation protein synthesis rate constant KD Given