Modeling the roles of 14-3-3 Σ and Wip1 in p53 dynamics and programmed cell death*

Nan Liu(刘楠),Hongli Yang(杨红丽),Liangui Yang(杨联贵)

Table 3. Robustness analysis of p53 oscillations.

Parameter Oscillation range Dd% Id% S ATMt 4.332–5.060 13.36% 1.20% 7.75% kpatm 0.214–0.253 14.40% 1.20% 8.35% ρ0 0.959–0.977 0.10% 17.71% 0.93% j0 4.883–6.614 2.34% 32.28% 15.06% kqatm 0.444–0.524 1.33% 16.44% 8.26% ρ1 0.665–1.000 30.00% 5.26% 20.12% j1 0.534–0.985 40.67% 9.44% 29.69% sp53 0.934–1.217 22.17% 1.42% 13.16% kqp53 0.787–1.060 1.63% 32.5% 14.78% ρ2 0.301–1.000 66.92% 9.89% 53.73% j2 0.216–1.009 76.00% 12.11% 64.73% kpp53 0.774–1.015 22.60% 1.50% 13.47% ρ3 0.959–0.991 0.10% 3.23% 1.64% j3 4.863–7.715 2.74% 54.30% 22.67% dp53 2.466–3.135 1.36% 25.40% 11.94% ρ4 0.882–0.973 9.07% 0.31% 4.91% j4 1.079–1.529 28.07% 1.93% 17.25% smdm2 4.218–5.976 1.91% 38.98% 17.25% ρ5 0.930–0.951 2.11% 0.11% 1.12% j5 0.651–2.073 56.60% 38.20% 52.20% kqmdm2 2.231–12.266 15.63% 308.87% 69.22% ρ6 0.000–1.000 100% 2.04% 100.00% j6 0.000–3.095 100% 243.89% 100.00% kpmdm2 0.977–2.723 60.92% 8.92% 47.19% ρ7 0.951–1.000 0.94% 4.17% 2.51% j7 4.269–50.336 14.62% 906.72% 84.36% dmdm2 0.691–1.054 32.91% 2.33% 20.80% ρ8 0.906–0.995 2.58% 6.99% 4.68% j8 0.682–0.923 2.57% 31.86% 15.02% swip1 0.152–0.216 5.00% 35.00% 17.39% ρ9 0.903–0.985 4.95% 3.68% 4.34% j9 0.308–0.358 12.00% 2.29% 7.51% dwip1 0.009–0.014 30.77% 7.69% 21.74% s14-3-3 Σ 0.379–0.513 24.20% 2.60% 15.02% ρ10 0.982–1.000 0.81% 1.01% 0.91% j10 0.397–0.434 0.75% 8.50% 4.45% d14-3-3 Σ 0.171–0.235 2.29% 34.29% 15.76% k1 0.082–0.313 18.00% 213.00% 58.48% k2 2.554–13.447 74.46% 34.47% 68.08%