Effects of rebinding rate and asymmetry in unbinding rate on cargo transport by multiple kinesin motors

Yao Wang,Yu-Ying Liu,Jian Liang,Peng-Ye Wang,Ping Xie

Figure 3. Dynamics of the cooperative transport by two identical kinesin motors with rebinding rate $\beta \mu .$ For kinesin-1 $\beta $ = 1, and for kinesi-2 $\beta $ = 4. Lines are simulated results. (a) Velocity ratio v2/v1 versus $\beta $ under no external force. (b) Run-length ratio L2/L1 versus $\beta $ under no external force. Symbols are experimental data from Feng et al [18], where K1–K1 represents the cooperative transport by two kinesin-1 motors and K1–K2 represents the cooperative transport by a kinesin-1 motor and a kinesin-2 motor. The errors of the experimental data are calculated with ${\rm{\Delta }}\left({L}_{2}/{L}_{1}\right)=\left|\partial \left({L}_{2}/{L}_{1}\right)/\partial {L}_{1}\right|$ ${\rm{\Delta }}{L}_{1}+\left|\partial \left({L}_{2}/{L}_{1}\right)/\partial {L}_{2}\right|{\rm{\Delta }}{L}_{2}.$ (c) Velocity v2 and run length L2 versus external force Fext for $\beta $ = 1 and $\alpha $ = 1. Inset shows stall force versus $\beta .$ (d) Velocity v2 and run length L2 versus external force Fext for $\beta $= 4 and $\alpha $ = 1.