Effects of rebinding rate and asymmetry in unbinding rate on cargo transport by multiple kinesin motors

Yao Wang,Yu-Ying Liu,Jian Liang,Peng-Ye Wang,Ping Xie

Figure 4. Dynamics of the cooperative transport by two different kinesin motors under no external force. One motor has velocity v1 and rebinding rate $\mu ,$ and the other has velocity ${v}_{1}/\alpha $ ($\alpha $ = 1.18) and rebinding rate $\beta \mu .$ (a) Velocity ratio v2/v1 versus $\beta .$ (b) Run-length ratio L2/L1 versus $\beta .$ (c) Velocity for transport by single kinesin-1 motor (K1), velocity for cooperative transport by two kinesin-1 motors (K1–K1) and velocity for cooperative transport by a kinesin-1 motor and a kinesin-2 motor (K1–K2). Kinesin-1 has velocity v1 and rebinding rate $\mu ,$ and kinesin-2 has velocity ${v}_{1}/\alpha $ ($\alpha $ = 1.18) and rebind rate $\beta \mu $ ($\beta $ = 4). (d) Run length for transport by single kinesin-1 motor (K1), run length for cooperative transport by two kinesin-1 motors (K1–K1) and run length for cooperative transport by a kinesin-1 motor and a kinesin-2 motor (K1–K2). For comparison, the experimental data of Feng et al [18] are also shown.