Balanced biosynthesis and trigger threshold resulting in a double adder mechanism of cell size control

Leilei Li

Figure 8. The Pearson correlation coefficients and slopes between birth size, replication initiation size, and added size in the replication-centric picture and division-centric picture when DNA initiation proteins are expressed periodically. Parameters of the dynamics systems are k = 3000 h−1, Σ = 3 ∗ 10−5 μm3 h−1, KD = 4 ∗ 10−12 h−1, KI = $9.2\ast {10}^{-12}\ast | \sin (t\ast \pi /1.446)| /\mathrm{hr}$, dR = dQ = dT = 0.1 h−1, and the other parameters of the model are shown in the table 1. (a) The mean added volume is unchangeable whatever the birth size is, in conflict with co-regulation theory. (b) The periodical oscillation expression of chromosome replication protein changes the initiation mass, destroying the replication adder.