Balanced biosynthesis and trigger threshold resulting in a double adder mechanism of cell size control

Leilei Li

Figure 9. The Pearson correlation coefficients and slopes between birth size, replication initiation size, and added size in the replication-centric picture and division-centric picture when division proteins are expressed periodically. Parameters of the dynamics systems are k = 3000 h−1, Σ = 3 ∗ 10−5 μm3 h−1, ${K}_{D}=4\ast {10}^{-12}\ast | \sin (t\ast \pi /1.446)| /\mathrm{hr}$, KI = 3.4 ∗ 10−12 h−1, dR = dQ = dT = 0.1 h−1, and the other parameters of the model are shown in the table 1. (a) The oscillation of division protein destroys adder property. The smaller the birth size is, the bigger the adder size. (b) DNA replication initiation is not influenced by periodical division protein production, and replication adder is kept.